Anticoagulation, endocrine and GI
Octreotide (Sandostatin) drip
Sandostatin
Dosing
| Start | 50 mcg bolus, then 50 mcg/h |
|---|---|
| Titrate | Fixed rate |
| Maximum | 50 mcg/h, for 2–5 days in variceal bleeding |
| Common bags | 500 mcg in 250 mL (2 mcg/mL); 1,000 mcg in 500 mL (2 mcg/mL) |
| Dose units | mcg/h |
Line and administration
- Peripheral or central
Watch for
- High or low glucose
- Bradycardia
Octreotide: full drug monographIndications, mechanism, pharmacokinetics, cautions and every dose the app lists.
In the one-pagers
- GI Bleeding, Liver Failure and PancreatitisUpper GI bleeding: Vasoactive drug: Octreotide as soon as suspected, 2–5 days
- Acute Abdomen and GI Surgical EmergenciesWhipple, bariatric and gastric surgery in depth: Dumping (Masclee 2023) follows gastric surgery, bypass and sleeve: up to 40% after bypass or sleeve. Early dumping (within 1 hour) is a fluid shift into the gut from hyperosmolar chyme: fullness, cramps, diarrhea, palpitations, sweating, faintness. Late dumping (1-3 hours) is reactive hypoglycemia. Treatment steps: smaller, more frequent meals rich
- LVAD BasicsComplications: bleeding, stroke, infection, RV failure: Hold warfarin (and aspirin in HeartMate II or HVAD patients), reverse only for life-threatening bleeding with a high INR, and scope early. For recurrent bleeding ISHLT 2023 lists a lower INR target, octreotide and thalidomide as options with thin evidence.
Practice GI Bleeding, Liver Failure and Pancreatitis questions free55 exam-style questions with rationales on the topic where octreotide comes up most. No account or download needed.
Other anticoagulation, endocrine and gi
- Heparin
- Insulin (regular)
- Amiodarone
- Diltiazem
- Pantoprazole
- Furosemide
- Argatroban
- Bivalirudin
- Procainamide
- Lidocaine
- Magnesium sulfate
- Naloxone
- Eptifibatide
- Bumetanide
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For education and exam preparation only. Follow your institution’s protocols. Study aid: check every dose against the order, the bag label, your pump library and your institution's protocol.